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Fig. 2 | Genome Biology

Fig. 2

From: The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance

Fig. 2

EC approach to represent a promoter-enhancer network and the preferred loop structure formed by the first enhancer in an EC with the target promoter. a The fraction of converged orientated CTCF motif pairs for enhancer-promoter and enhancer-enhancer loops in the GM12878 cell line. b The top enriched transcription factor binding sites (TFBSs) in E1s compared to E2s directly, in GM12878 and K562 cell lines. The loop factors are labeled in orange. Red and blue represent the enriched TFBSs in E1s and E2s, respectively. c The fraction of enhancers along the chains that overlap the loop boundaries. d The fraction of Hi-C contacts formed between enhancers and other enhancers/promoters in two different sub-topologically associating domains (sub-TADs). *p <  0.05, **p < 0.001, ***p < 1 × 10−10; p values are calculated using the binomial test

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