Fig. 1
The first enhancer in an enhancer chain (EC) is distal from the target promoter (P). a The genomic distance between the enhancers [step-one (E1), step-two (E2), step-three, and the rest (E3+)] along the chain and their target Ps. b The distance between E2 and P is shorter than the distance between E1 and P. c E1 skips more genes to contact the target gene than E2. d The proportion of ECs for different cases according to the relative genomic positions of the enhancers in a chain. The red lines indicate the two most frequent organizing patterns of P, E1, E2, and, later, E3, according to their relative positions along the genome. e Schematic plot of a possible model for 3D organization processes of an EC in Scenario 1. **p < 0.001, ***p < 1 × 10−10; p values are calculated using the Wilcoxon rank-sum test and the binomial test