Fig. 3

Methylation associations with expression. a Venn diagrams of the methylation associations by unique feature for the gene, exon, and PSI. The sets are determined by if the association is FDR < 5% genome-wide for CpG and CpH or if it is a CpG marginally significant within ± 1-kb window of a CpH association. b Example associations between methylation and expression at the gene level colored by age: red, infant; orange, child; green, teen; blue, adult. GUCY1A3 contains one of the top CpH differentially expressed between neurons and glia. Expression of an exon of TTN, an autism-associated gene, is negatively associated with mCpH. DOCK1 PSI of an alternative end site is negatively associated with mCpH. c Enriched molecular function ontology terms for methylation-associated exons by the Venn diagram groups from a