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Table 1 The enrichment statistical significance for different minimal expression cutoffs

From: DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

Cutoff

Schizophrenia

Bipolar disorder

 

Brain-anterior cingulate cortex (BA24)

Brain-frontal cortex (BA9)

Brain-cortex

Brain-cerebellar hemisphere

Brain-cerebellum

Brain-frontal cortex (BA9)

0.01

5.3E−13

5.3E−13

1.8E−12

1.3E−9

7.3E−09

1.6E−6

0.5

9.3E−8

1.3E−7

7E−8

1.7E−5

1.9E−5

6.4E−3

1.0

3.8E−7

1.5E−6

7.1E−7

3.0E−5

5.0E−5

0.024

 

Coronary artery disease

Rheumatoid arthritis

 

Artery-coronary

Adrenal gland

Ovary

Small intestine-terminal ileum

Lung

Spleen

0.01

4.3E−6

1.7E−5

6.1E−6

5.5E−11

4.2E−9

7E−8

0.5

4.2E−4

8.9E−3

2.9E−5

6.3E−7

2.9E−8

6E−5

1.0

4.2E−3

4.7E−2

1.8E−4

1.2E−6

5.2E−8

1.7E−4

 

Total cholesterol

Height

 

Liver

Lung

Spleen

Cells-transformed fibroblasts

Heart-atrial appendage

Lung

0.01

6.9E−8

3.3E−5

3.5E−5

1.3E−11

6E−12

5.3E−11

0.5

9.1E−5

1E−2

2.6E−2

1.9E−2

3.7E−3

6.6E−5

1.0

9.7E−3

6.4E−3

5.5E−2

4.3E−2

5.5E−3

1.5E−4

  1. Note: The p values of driver tissues were calculated according to the proposed robust-regression z-scores. According to a cutoff x, gene or transcripts having TPM < x in 40 or more tissues were excluded