Skip to main content

Table 1 The enrichment statistical significance for different minimal expression cutoffs

From: DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

CutoffSchizophreniaBipolar disorder
 Brain-anterior cingulate cortex (BA24)Brain-frontal cortex (BA9)Brain-cortexBrain-cerebellar hemisphereBrain-cerebellumBrain-frontal cortex (BA9)
0.015.3E−135.3E−131.8E−121.3E−97.3E−091.6E−6
0.59.3E−81.3E−77E−81.7E−51.9E−56.4E−3
1.03.8E−71.5E−67.1E−73.0E−55.0E−50.024
 Coronary artery diseaseRheumatoid arthritis
 Artery-coronaryAdrenal glandOvarySmall intestine-terminal ileumLungSpleen
0.014.3E−61.7E−56.1E−65.5E−114.2E−97E−8
0.54.2E−48.9E−32.9E−56.3E−72.9E−86E−5
1.04.2E−34.7E−21.8E−41.2E−65.2E−81.7E−4
 Total cholesterolHeight
 LiverLungSpleenCells-transformed fibroblastsHeart-atrial appendageLung
0.016.9E−83.3E−53.5E−51.3E−116E−125.3E−11
0.59.1E−51E−22.6E−21.9E−23.7E−36.6E−5
1.09.7E−36.4E−35.5E−24.3E−25.5E−31.5E−4
  1. Note: The p values of driver tissues were calculated according to the proposed robust-regression z-scores. According to a cutoff x, gene or transcripts having TPM < x in 40 or more tissues were excluded