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Fig. 3 | Genome Biology

Fig. 3

From: DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

Fig. 3

Driver tissues estimated by DESE and two exiting methods in six representative complex diseases/traits. Note: Each row shows one disease/trait. The first, second, and third columns show the estimated driver tissues according to GTEx transcript-level, GTEx gene-level, and GEO gene-level selective expression respectively. The bar denotes the averaged -log10(p) based on selective expression of four different measures. The -log10(p) based on each selective expression measure is denoted by a line. The fourth column shows estimated driver tissues by Ongen et al.’s method, which is extracted from Supplementary Table 5 of their published paper [10]. The fifth column shows estimated driver tissues by the LDSC-SEG method, which is extracted from Supplementary Table 6 of their published paper [11]. The pink horizontal denotes the significance level. The tissues are classified into 15 groups according to anatomy. The tissues are sorted by the averaged -log10(p) on y axis in descending order. SCZ schizophrenia, BD bipolar disorder, CAD coronary artery disease, RA rheumatoid arthritis, TC total cholesterol

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