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Fig. 1 | Genome Biology

Fig. 1

From: Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes

Fig. 1

Genomic GPS and its application to sample overlap detection. a The concept of conventional GPS. Distances to satellites are used to compute an aircraft’s location. b The concept of genomic GPS. The genetic distances of an individual to reference individuals in public datasets are calculated to create a distance vector. c Distance vectors can be shared, for example, by using a public data hub. d Sample overlap detection using distance vectors. The distance vectors of two individuals are compared using a statistic that follows a χ2 distribution. e The power of the sample overlap detection method as a function of the number of loci and the number of reference individuals used to calculate the genetic distances. f P values of the sample overlap detection method for overlapping pairs and unrelated pairs in the simulations using the WTCCC data

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