Fig. 5From: Identifying significantly impacted pathways: a comprehensive review and assessmentThe process of creating the null distributions of p values for all pathways by a given pathway analysis method. Control samples from data sets are gathered to construct a control sample pool. To create the null distribution of p values of all pathways under the null for each method, more than 2000 iterations were performed. The data sets used in these iterations are generated by randomly selecting samples from the control sample poolBack to article page