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Fig. 4 | Genome Biology

Fig. 4

From: Regulation of rumen development in neonatal ruminants through microbial metagenomes and host transcriptomes

Fig. 4

Association between rumen miRNA profile (expression of miRNA) and rumen microbiota (bacterial genera, concentration of VFAs). a Relationship between the miRNA modules (miRNA modules define as R1–R9) and calf phenotypic traits. miRNA modules are generated using WGCNA, and eigengene/PC1 values of each modules are correlated with calf phenotypic traits. Numerical values within a square represent Pearson correlation (upper value) and P value (lower value). Color bar represents Pearson correlation from − 1 to 1. b Temporal changes in the expression (CPM) of miR-375 in calf rumen (day 0, 605.1 ± 40.3; week 1, 171.5 ± 15.6; week 3, 10.9 ± 3.8; week 6, 2.9 ± 1.2; P < 0.01). Fold change (FC) is the expression ratio between two adjacent age groups. c Functions of mir-375 predicted using TargetScan and miRbase. d Association between rumen bacterial taxonomy and miRNAs co-expressed in the R7 miRNA module

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