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Table 1 List of selected genome-scale metabolic reconstruction tools and their main features

From: A systematic assessment of current genome-scale metabolic reconstruction tools

Reconstruction tool

Mapping method

Reactions are inherited from

Associated databases

Version

Type of software

AuReMe

Pantograph (Inparanoid and OrthoMCL)

Template model(s)

BIGG-MetaCyc

1.2.4

Command line

CarveMe

Diamond, eggNOG-mappera

Template model

BIGG

1.2.1

Command line

Merlin

Mapping from annotation with BLAST or HMMER

Database

KEGG

3.8

Standalone interface

MetaDraft

Autograph (Inparanoid)

Template model(s)

BIGG

0.9.2

Standalone interface

ModelSEED

Annotation ontology map from RAST data

Template model

ModelSEED

2.2–2.4

Online service

Pathway Tools

Pathologic

Database

MetaCyc

22.0

Standalone interface

RAVEN

Autograph-type method from BLASTP and Bidirectional BLASTPb

Database- Template model(s)

KEGG-MetaCyc

2.0.1

Command line

  1. aeggNOG-mapper should be run externally by the user
  2. bBidireactional BLASTP is used with template models and BLASTP with databases (KEGG and Metacyc)