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Fig. 2 | Genome Biology

Fig. 2

From: Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control

Fig. 2

m6a methylation suppresses exonization. a Barplots of m6a-methylation associated genes and the number of novel exons identified upon knockdown in HepG2 cells b Barplot showing number of exonization events induced upon knockdown of N6-adenosine-methyltransferase (METTL3) compared to a control sample. p value calculated using Wilcoxon-rank sum test. c Boxplots displaying normalized intronic m6a peaks per nucleotide from nascent RNA in HepG2 cells. Genomewide Alu elements occur within expressed introns with no identified exonization events. Boxplots display the interquartile range as a solid box, 1.5 times the interquartile range as vertical thin lines, the median as a horizontal line, and the confidence interval around the median as a notch. nt, nucleotide (n = 13,247). d Plot showing relative m6a coverage in nucleotides surrounding Alu elements. See c for the description of “genome-wide”. (n = 13,247)

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