Fig. 2

Benchmarking results of RaPID, GERMLINE, and IBDseq for IBD detection in a sequencing platform. Simulated sequences of 4000 haplotypes with a chromosome length of 10 Mbps were generated by macs. a Run time: the time for RaPID was for the target length of 3 cM. b Power: the average proportion of true IBD segments that have been reported. c Accuracy: the number of correctly detected IBDs that share at least 50% overlap with the true IBDs over the number of reported IBDs. d Length discrepancy of detected segments: the root mean squared difference in terms of lengths between the correctly detected IBDs and the true IBDs. Parameters of GERMLINE and IBDseq were tuned with due diligence and according to previous literature (see the “Benchmarking using simulated data” section) but may not be fully optimized