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Fig. 4 | Genome Biology

Fig. 4

From: Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

Fig. 4

Analysis of methylation Shannon entropy during physiological aging and in Sotos syndrome. a Scatterplot showing the relation between genome-wide Shannon entropy (i.e., calculated using the methylation levels of all the CpG sites in the array) and chronological age of the samples for Sotos (orange) and healthy controls (gray). Each sample is represented by one point. b Boxplots showing the distributions of genome-wide Shannon entropy acceleration (i.e., deviations from the expected genome-wide Shannon entropy for their age) for the control and Sotos samples. The p value displayed on top of the boxplots was derived from a two-sided Wilcoxon’s test. c Same as a., but using the Shannon entropy calculated only for the 353 CpG sites in the Horvath epigenetic clock. d Same as b, but using the Shannon entropy calculated only for the 353 CpG sites in the Horvath epigenetic clock

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