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Fig. 4 | Genome Biology

Fig. 4

From: Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene

Fig. 4

Topologically associated domains (TADs) in teloHAEC endothelial cells treated with TNFα. a Because TADs have different sizes across the genome, we normalized them after adding 35 kb on either side to define boundaries. From ENCODE Project data in HUVECs, we retrieved CTCF binding sites from ChIPseq and enhancers defined with histone marks. We used our own RNAseq data in teloHAEC to define transcription start sites (TSS). In b and c, we map the relative position of coronary artery disease (CAD)- and blood pressure (BP)-associated SNPs into teloHAEC TADs. For comparison, we also added the distribution of relative positions for non-associated, matched (control) SNPs. Similar results were observed for TADs in non-treated teloHAEC (Additional file 10)

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