Fig. 2From: CONFINED: distinguishing biological from technical sources of variation by leveraging multiple methylation datasetsA comparison of CONFINED and previous reference-free methods in capturing leukocyte composition. We used each methods’ components to capture cell-type proportions as estimated by the reference-based method of Houseman et al. [19] across CD4 T cells, CD8 T cells, monocytes, B cells, natural killer cells, and granulocytes in whole-blood data from an aging study (here; Additional file 1: Figure S3 Hannum et al. [38]) as well as in whole-blood from a study of Rheumatoid arthritis (Liu et al. [39] Additional file 1: Figure S4)Back to article page