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Table 1 A comparison of the approaches of Sood et al. and Jacob and Speed

From: A statistical and biological response to an informatics appraisal of healthy aging gene signatures

Performance criteria Sood et al. Jacob and Speed
Hypothesis driven gene selection in independent samples Yes No
Tissue age ROC performance externally validated Yes No
Multi-tissue age classification achieved Yes No
Longitudinal health association achieved Yes No
Top age gene-set statistically tested in blood Yes No
ROC performance assessed within an AD cohort Yes Yes
Top gene-set statistically significant across AD cohorts Yes No
Top gene-set independently linked to age and dementia Yes No
Gene-set trained in AD clinical cohort No Yes