A statistical and biological response to an informatics appraisal of healthy aging gene signatures

Table 1 A comparison of the approaches of Sood et al. and Jacob and Speed

Performance criteria	Sood et al.	Jacob and Speed
Hypothesis driven gene selection in independent samples	Yes	No
Tissue age ROC performance externally validated	Yes	No
Multi-tissue age classification achieved	Yes	No
Longitudinal health association achieved	Yes	No
Top age gene-set statistically tested in blood	Yes	No
ROC performance assessed within an AD cohort	Yes	Yes
Top gene-set statistically significant across AD cohorts	Yes	No
Top gene-set independently linked to age and dementia	Yes	No
Gene-set trained in AD clinical cohort	No	Yes

ISSN: 1474-760X