Fig. 2

TISs interact with KEEs and pericentromeric regions. Differential analysis of 4C interactomes, including 3 wild-type and 3 transgenic 4C samples. Log2 fold changes (FC) are plotted. Gray: non-significant FC (FDR > 0.05). Red: significant FC (FDR ≤ 0.05). Orange triangles indicate viewpoints (adjacent to TIS on endogenous sequence). Blue triangles and dashed blue lines indicate positions of KEEs. Gray rectangles delineate pericentromeric regions. Interaction frequencies of single HindIII restriction fragments were pooled into 100-kb genomic bins. Yellow arrows indicate significant TIS-KEE contacts, for which magnification is given on the left