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Fig. 4 | Genome Biology

Fig. 4

From: Chromatin accessibility plays a key role in selective targeting of Hox proteins

Fig. 4

Roles of chromatin accessibility and affinity in Hox selectivity. a Boxplot showing relationship of Hox selectivity to chromatin accessibility (ATAC score). Hox selectivity is represented by binning Hox group peak regions according to the number of Hox proteins bound; 1-Hox: only 1 Hox protein bound; 8-Hox: all 8 Hox proteins are bound. Number of regions in each Hox selectivity bin is shown above the plot. b Plot showing relationship of Hox selectivity classes to chromatin accessibility. The Hox group peaks are then separated into ATAC score bins and the frequency of Hox selectivity classes (see scale) is plotted. c Plot showing opposing distributions of sites binding all Hox proteins (8-Hox) and uniquely bound sites (1-Hox) with respect to chromatin accessibility (ATAC score bins). d Plots showing relationship between Hox selectivity and (from left) TBA (for each 7-mer Hox PWM from the JASPAR database), mean number of occurrences of Hox motifs (using matchPWM function with min.score = 80%) and highest PWM match score within each region for binding regions as in a. e Relationship between Hox selectivity and TBA for sets of binding regions for particular Hox proteins. Left for the regions bound by Dfd and right for the regions bound by Abd-B, plotting the TBAs for the Dfd (orange) and Abd-B (purple) motifs

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