Fig. 3
From: Chromatin accessibility plays a key role in selective targeting of Hox proteins
Roles of chromatin accessibility and affinity in Hox binding. a Density plots of mean ATAC-seq scores for Hox group peak regions (200 bp regions). Left plot anterior Hox proteins, right plot posterior Hox proteins. b HoxA (consensus motif combining Lab, Pb, Dfd, Scr, Antp, Ubx, Abd-A motifs) and HoxB motifs. c Boxplot of the total binding affinity (TBA) for HoxA (grey) and HoxB (purple) motifs for the top 500 binding regions for each Hox protein. d Plots of Hox group peak regions for each Hox protein classified according to the number of motif matches (HoxA on left, HoxB on right) they contain (see scale). For each Hox protein, matches were counted in the top 500 (by ChIP score) Hox group peak regions using the matchPWM function in Biostrings R package with min.score = 90%. e Boxplot showing relationship of TBA and chromatin accessibility, with HoxA (upper) and HoxB (lower) TBA for regions bound by any Hox binned by ATAC score