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Fig. 10 | Genome Biology

Fig. 10

From: Chromatin accessibility plays a key role in selective targeting of Hox proteins

Fig. 10

Hox occupancy is more strongly associated with binding region chromatin accessibility than with binding affinity. a Scatter plots of chromatin accessibility (log[ATAC scores]) versus binding affinity (log[TBA HoxA]) for chromatin regions classified as “open.” Open chromatin regions were divided into 200bp tiles and the mean ATAC score and TBA for HoxA PWM calculated per tile. The log of these scores was then linearly binned into 40 bins on each axis. For the “All regions” plot, the heatmap shows the density distribution. For the other plots, the heatmap shows the percentage of tiles bound by the specified Hox protein per bin or for “No Hox” the percentage of tiles not bound by any Hox protein. Note that bins with zero percent are given background colour in the heatmap scale. The plots are shown for selected Hox proteins and for TBA for the HoxA PWM (for a fuller set of plots including HoxB TBA, see Additional file 1: Figure S6). b Scatter plots show the strong correlation of occupancy (% per bin) with chromatin accessibility (log[ATAC scores]; upper row) and the poor correlation with binding affinity ((log[TBA HoxA]; lower row). Data as in a. Further plots in Additional file 1: Figure S6

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