Fig. 7
From: Single-cell transcriptomics unveils gene regulatory network plasticity
Rewiring of regulatory network in Alzheimer’s disease microglia introduces information bottlenecks. a MSigDB enrichments for 10 lists of genes with altered centrality in AD compared to control network (5 centralities, 719 MSigDB terms were found to be enriched with p < 0.05 in at least one entry). The results show that the tested centralities provide insights into different functional pathways. b The AD regulatory network follows a circular shape in which the nodes along the terminal tail (yellow genes) become bottlenecks, i.e., acquire increased betweenness. The exact increase in betweenness is represented in the histogram. c International Mouse Phenotyping Consortium data for the transcript 2700060E02Rik, alias Rtraf. Homozygous 2700060E02Rik knockout is associated with embryonic lethality prior to tooth bud stage and heterozygous 2700060E02Rik knockout is associated with tremors, hypoactivity, and increased eosinophil cell number