Fig. 2
From: A genomic atlas of systemic interindividual epigenetic variation in humans
Distribution and characteristics of 9926 human CoRSIVs. a Scatter plot of CoRSIV size vs. CpGs per CoRSIV. b Circos plot of human autosomes indicates regions of high CoRSIV density. c Individual methylation levels across examples of CoRSIVs from each of the two most high-density regions: (left) HLA-C (chromosome 6) and (right) DUX4L35 (chromosome 20). d Compared to all informative bins, CoRSIVs are more than twofold enriched in sub-telomeric regions (χ2 test P < 10− 300). e Compared to control regions or tissue-specific differentially methylated regions (tDMRs), CoRSIVs are enriched for repetitive elements and depleted for CpG islands (CGI) and transcription binding sites (TFbs) (χ2 test P < 10− 8 for all comparisons). f Relative to control and tDMR regions, CoRSIVs are under-represented at transcription start sites (TSS), within gene bodies, and at transcription end sites (TES) (χ2 test P < 10− 16 for all comparisons). g ChromHMM epigenomic features significantly enriched or depleted in CoRSIVs