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Fig. 2 | Genome Biology

Fig. 2

From: ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Fig. 2

ChiCMaxima precisely calls chromatin interactions. a mES CHi-C (upper panel) and 4C (lower panel) profiles centered on the bait Dek promoter are shown. The interactions called by ChiCMaxima and CHiCAGO are denoted as stripes (gray and pink, respectively); points denote interactions called by GOTHiC. GOTHiC seemingly calls many spurious interactions. b mES CHi-C (upper panel) and 4C (lower panel) profiles centered on the bait Hoxc5 promoter are shown. The interactions called by ChiCMaxima are denoted as gray stripes, and a large number of seemingly spurious interactions called by CHiCAGO are denoted as red points. Called interactions conserved between ChiCMaxima and CHiCAGO are centered on CTCF sites. For both profiles, gene position (blue) and CTCF ChIP-seq profiles (dark green) are shown below the CHi-C and 4C profiles

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Genome Biology

ISSN: 1474-760X

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