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Fig. 6 | Genome Biology

Fig. 6

From: Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex

Fig. 6

circQTL SNPs enriched in GWAS loci. a Enrichment of pruning max-circQTL SNPs among the GWAS Catalog. The circle size is proportional to the number of overlapping SNPs between GWAS loci and pruning max-circQTLs. The dashed horizontal line indicates an FDR = 0.01, the solid horizontal line indicates an FDR = 0.05, and the dashed vertical line indicates an OR = 1, one-tailed FET. AGA: androgenetic alopecia; BC: breast carcinoma; BP: bipolar disorder; CAD: coronary artery disease; IBD: inflammatory bowel disease; T2DM: type II diabetes mellitus. bd Local plots of circQTL SNPs with high linkage disequilibrium (r2 > 0.8) with GWAS results of b schizophrenia [35], c inflammatory bowel disease [36], and d type II diabetes mellitus [37] were generated by LocusZoom [38]. The most significant GWAS SNPs are colored purple. Nearby SNPs are color-coded according to their LD (r2). The back-splicing region is highlighted in purple. The statistical strength of the association (− log10 P values) and recombination rate are double-plotted on the y-axis. Genes in the UCSC Genome Browser are shown in the panels below the local plots

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