Fig. 5

Impacts of the canonical splice site on circRNA expression. Violin plots of covariate-adjusted circRNA and gene expression within each genotype are shown in the left panels. The overlaid boxplots indicate the median (horizontal black lines) and interquartile range (IQR, white boxes). Outliers are shown as black dots. Schematic of transcript isoforms at each locus (Ensembl Gene Predictions tracks from the UCSC Genome Browser) are shown in the right panels. The back-splicing region is highlighted in purple. Arrowheads indicate the splice sites. a circQTL SNP at the canonical back-splicing site in TBC1D31. b circQTL SNP at the circRNA internal canonical splice site in NEK10. c circQTL SNP at the circRNA external canonical splice site in SPATA7