Fig. 3

Identification of cis-circQTLs. a, b circQTLs detected by circCPM and the circular ratio for exonic (a) and intronic (b) circRNAs. c The concordant effects of circQTLs detected by the circCPM and circular ratio methods. d The effects of circQTLs vs. eQTLs. e, f One example of a discordant QTL between a circRNA and its host gene. The center line denotes the median, the limits are the interquartile range (IQR), the whiskers are 1.5× the IQR, and outliers are shown as black dots. f The expression level of the circRNA and the gene in each sample. The red, yellow, and blue lines fit the expression between the gene and circRNA according to the CC, TC, and TT genotypes, respectively