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Fig. 3 | Genome Biology

Fig. 3

From: VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Fig. 3

ER occupancy after estradiol treatment in terms of TF network activity. (a) Global TF network behavior as predicted by VULCAN in our ChIP-seq dataset, highlighting the ESR1 TF at time 0 and 45/90 min after estradiol treatment. (b) Global TF activity after estradiol treatment in MCF7 cells, inferred using the METABRIC network, highlighting TFs significantly upregulated at 45 min and 90 min. (c) Global TF activity after estradiol treatment in MCF7 cells, inferred using the METABRIC network, highlighting TFs significantly downregulated at 45 min and 90 min. (d) Global TF activity after estradiol treatment in MCF7 cells, inferred using the METABRIC network, highlighting TFs significantly upregulated at 45 min but not at 90 min. (e) Global TF activity after estradiol treatment in MCF7 cells, inferred using the METABRIC network, highlighting TFs significantly upregulated at 90 min but not at 45 min. (f) Most enriched motif in peaks upregulated at both 45 and 90 min after estradiol treatment, as predicted by HOMER

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Genome Biology

ISSN: 1474-760X

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