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Fig. 10 | Genome Biology

Fig. 10

From: VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Fig. 10

Overview of the role of GRHL2 in ER activation. On activation of the ER by the ligand E2, the protein is released from a complex containing HSPs and translocates to the nucleus. The holo-ER dimer forms a core complex at estrogen response elements (ERE) with FOXA1 (pioneer factor) and GATA3. ER further recruits P300 and GRHL2. GRHL2 has an inhibitory effect on P300 (a transcriptional activator interacting with TFIID, TFIIB, and RNAPII), thereby reducing the level of eRNA transcription at enhancer sites. Overexpression of GRHL2 further suppresses transcription, while knockdown of GRHL2 reverses the process

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Genome Biology

ISSN: 1474-760X

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