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Fig. 6 | Genome Biology

Fig. 6

From: Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway

Fig. 6

β-catenin-370aa functioned as a decoy for GSK3β and antagonized GSK3β-mediated β-catenin degradation. a The phosphorylation status of β-catenin was examined by western blot in Huh7 cells. b IP experiment was performed to evaluate the interaction between β-catenin-370aa and GSK3β in Huh7 cells. c The binding capacity between β-catenin and GSK3β was monitored by co-IP in circβ-catenin knockdown Huh7 cells and corresponding control cells. d After transient overexpression of β-catenin-370aa, the binding capacity between β-catenin and GSK3β was monitored by co-IP. e In liver cancer cells with stable knockdown of circβ-catenin, western blot was conducted to examine the endogenous β-catenin-associated ubiquitination after immunoprecipitation with anti-β-catenin antibody in Huh7 cells. f Schematic diagram of a hypothetical model

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