Skip to main content
Fig. 2 | Genome Biology

Fig. 2

From: Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway

Fig. 2

Knockdown of circβ-catenin suppressed in vitro liver cancer cell proliferation and migration. a The RNA levels of circβ-catenin were examined in HCC patients (n = 50). b After stable knockdown of circβ-catenin, the RNA levels of circβ-catenin and β-catenin mRNA were examined in two liver cancer cell lines. c MTT assay was performed to monitor the effect of circβ-catenin in cell proliferation (n = 6). d After stable knockdown of circβ-catenin, colony formation assay was conducted (n = 5). e The effect of circβ-catenin in modulating cell cycle progression was evaluated by flow cytometry assay (n = 5). f The effect of circβ-catenin on cell migration was examined by wound healing assay (n = 5). g The effect of circβ-catenin on cell invasion was examined by Boyden chamber assay (n = 4) (*P < 0.05, **P < 0.01)

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us