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Fig. 6 | Genome Biology

Fig. 6

From: DegNorm: normalization of generalized transcript degradation improves accuracy in RNA-seq analysis

Fig. 6

Examples illustrating that DegNorm improves accuracy in RNA-seq DE analysis. a, b Coverage curves under UQ and DegNorm normalization methods side-by-side for gene MMP14 in GBM R10vsR4 comparison. Same coverage plots for PIK3C2A (c, d) and NDUFV3 (e, f) genes, respectively, in the SEQC-AB comparison. All three genes changed from positive to negative after degradation normalization in DE analysis using edgeR. In (e, f), annotated exon boundaries are plotted to show possible alternative splicing in the exon from 223 to 1327‚ÄČnt

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