Fig. 6
From: SCRABBLE: single-cell RNA-seq imputation constrained by bulk RNA-seq data
Pairwise expression correlation among pathway genes is improved using imputed data. A pathway gene correlation score (PGCS) measures the increase in expression correlation among pathway genes compared to a set of randomly selected genes of the same size. ΔPGCS is the difference in PGCS between imputed data and un-imputed data. For each data set (dropout or imputed data), a ΔPGCS value is computed for each pathway. Boxplot represents ΔPGCS values for 186 pathways in the IPA database. P value is based on Student’s t test. a Human h1 ES cells data (H1). b Human trophoblast (TB)-like cells data. c Human foreskin fibroblast cells (HFF)