Table 1 Melissa robustly imputes CpG methylation states on sub-sampled ENCODE scRRBS and scWGBS synthetic data. Entries with italics denote the model with the highest performance in terms of AUC
From: Melissa: Bayesian clustering and imputation of single-cell methylomes
| Â | Pseudo scRRBS | Pseudo scWGBS | ||
|---|---|---|---|---|
Model | AUC 20% cov | AUC 50% cov | AUC 20% cov | AUC 50% cov |
Melissa | 0.96 (7.3×10−4) | 0.96 (6.8×10−4) | 0.96 (6.3×10−4) | 0.96 (6.6×10−4) |
DeepCpG | 0.94 (1.5×10−3) | 0.94 (1.5×10−3) | 0.96 (1.4×10−3) | 0.96 (1.4×10−3) |
BPRMeth | 0.88 (2.2×10−3) | 0.91 (2.5×10−3) | 0.90 (1.9×10−3) | 0.92 (1.5×10−3) |
RF | 0.79 (3.2×10−3) | 0.87 (2.0×10−3) | 0.83 (2.2×10−3) | 0.89 (2.1×10−3) |
Melissa rate | 0.88 (1.8×10−3) | 0.88 (1.3×10−3) | 0.70 (2.2×10−3) | 0.71 (2.5×10−3) |
Rate | 0.82 (2.6×10−3) | 0.84 (2.5×10−3) | 0.76 (4.2×10−3) | 0.77 (3.0×10−3) |