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Fig. 5 | Genome Biology

Fig. 5

From: Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors

Fig. 5

Predicting sensitivity to deacetylase inhibitors by inferring basal metabolic network state. a Schematic overview of the analysis comparing the sensitivity of cell lines from CCLE to deacetylase inhibitors and their corresponding metabolic state. b The histogram shows the distribution of predicted acetylation flux (mmol/gDW cells/h) among the CCLE cell lines. The data revealed two groups of cell lines—cell lines predicted to have no or very low acetylation flux (flux < 0.05) and a high flux group (flux > 0.05). c KDAC inhibitors, vorinostat, panobinostat, belinostat, and entinostat, were significantly more sensitive against the high flux group than the low flux group of cell lines (p value < 10− 5, t-test; Additional file 1: Figure S3). The bar graphs depict the area under the growth curve (AUC) of CCLE cell lines after treatment with the drugs, with lower AUC implying greater growth inhibition. The results are robust to the cut-offs for high and low acetylation flux group (Additional file 1: Figure S3)

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