Fig. 1

Generating ATAC-seq libraries without the usage of lysis buffer increases agreement with DNase-seq. a Percentage of all reads that align to the mitochondrial genome in K562 ATAC-seq libraries generated with the published protocol (10 min lysis), shorter lysis (5 min lysis), or without using lysis buffer (no lysis buffer). b Agreement of these libraries with all K562 DNase-seq libraries as measured by Pearson correlations of read counts in 100 bp bins genome-wide. c Overlap of peaks found in K562 DNase-seq data with peaks in ATAC-seq data generated using the published protocol (left) and peaks in ATAC-seq data generated without using lysis buffer (right)