Table 1 Evolutionary conservation of C>U recoding RNA editing sites in translational and ribosomal genes
From: Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells
Mutation | Gene | AAChange | PolyPhen | SIFT | PhiloP |
|---|---|---|---|---|---|
1:32231146-CT | EIF3I | NM_003757:exon11:c.C928T:p.R310C | Possibly damaging (0.901) | Deleterious (0) | 2.64453 |
15:55196824-GA | RSL24D1 | NM_016304:exon1:c.C67T:p.R23C | Benign (0.011) | Deleterious (0.02) | 3.43396 |
6:35470271-CT | RPL10A | NM_007104:exon5:c.C403T:p.P135S | Possibly damaging (0.866) | Deleterious (0.01) | 7.64955 |
19:17863201-CT | RPL18A | NM_000980:exon5:c.C469T:p.R157W | Benign (0.12) | Deleterious (0.03) | 3.41186 |
17:28720820-CT | RPL23A | NM_000984:exon2:c.C139T:p.R47W | Benign (0.013) | Tolerated (0.28) | 1.92739 |
19:39433341-GA | RPS16 | NM_001020:exon5:c.C373T:p.R125C | Possibly damaging (0.901) | Deleterious (0.03) | 7.59689 |
16:1962610-GA | RPS2 | NM_002952:exon6:c.C596T:p.P199L | Possibly damaging (0.905) | Deleterious (0.03) | 9.862 |
1:39561754-GA | PABPC4 | NM_001135653:exon15:c.C1927T:p.H643Y | Benign (0.063) | Deleterious (0.02) | 10.003 |