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Fig. 7 | Genome Biology

Fig. 7

From: Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells

Fig. 7

Simplified diagram summarizing the induction and relevance of A3G-mediated site-specific C>U cellular mRNA editing in NK cells and lymphoma cell lines. NK/lymphoma cell is shown under normal physiological conditions when the cells are unstressed (left) or when the cells are stressed by hypoxia (top right) or due to the inhibition of mitochondrial respiration (bottom right). Under normal physiological conditions (baseline), mRNAs (stem-loop) in NK cells do not undergo C>U RNA editing. Under hypoxic stress or upon mitochondrial respiratory inhibition, an unknown signal originating in the mitochondria triggers site-specific A3G-mediated C>U editing in multiple mRNA substrates bearing a stem-loop structure. The cellular mRNA editing induced by mitochondrial hypoxic stress may result in translational reprogramming of NK cells, Warburg-like metabolic remodeling by preferring glycolysis over mitochondrial respiration and support cellular proliferation in order to promote adaption during NK/lymphoma cell stress

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