Fig. 6

dStruct reported riboSNitches from a PARS dataset. a The within-group Pearson correlation coefficients (green bars) for riboSNitches reported by dStruct were higher than their respective between-group Pearson correlations (red bars). b Example of reactivity profiles for the mother, the child, and the father for one of the regions that dStruct reported as riboSNitch, i.e., the single-nucleotide variant at site 1817 for NM_032855. Note that for this region, the mother and child were allelically identical and therefore labeled as group A (A1 and A2). They appear identical, but they differ from the father, who had a different allele and was labeled as group B (B1). c A histogram of the differences between Pearson correlation coefficients between and within groups. Many of the riboSNitches reported by StrucDiff had only a minor change in their Pearson correlation. For many of the regions, the between-group Pearson correlations were also higher. The dotted vertical line in red marks the median of distribution