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Fig. 4 | Genome Biology

Fig. 4

From: dStruct: identifying differentially reactive regions from RNA structurome profiling data

Fig. 4

dStruct identified DRRs from a ligand-mediated structure alteration. Fluoride ions bind the crcB fluoride riboswitch and alter its structure. a Secondary structure in the absence of fluoride ions. b Secondary structure in the presence of 10 mM fluoride ions. The red curves highlight the pseudoknot between nucleotides 12–17 and 42–47. The purple curves highlight long-range interactions between the nucleotide pairs (10, 38) and (40, 48). c Eight samples of reactivity profiles, four from group A (A1, A2, A3, and A4) with 0 mM fluoride ions and four from group B (B1, B2, B3, and B4) with 10 mM fluoride ions. Solid blue lines mark DRRs that are considered as the ground truth. Hollow black rectangles mark the DRRs called by deltaSHAPE. A red background marks the DRRs called by dStruct. A green line marks the DRR called by PARCEL. Note that RASA did not report any DRRs

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