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Table 3 Summary of top-ranking miRNA targeting features identified by RFE analysis

From: Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data

Feature name RFE rank Targets Non-targets P value
Seed 8A1, conserved 1 0.184 0.018 2.8E−245
Seed7b, low phyloP score 2 0.273 0.445 3.2E−84
GC content of target site 3 1.554 1.901 4.9E−117
UTR length (log2) 4 10.960 11.430 1.5E−114
Seed7A1, non-conserved 5 0.142 0.341 9.5E−134
Seed7A1, low phyloP score 6 0.137 0.339 1.3E−138
AG count 7 0.517 0.774 2.6E−73
Seed8A1, low phyloP score 8 0.200 0.126 1.5E−29
Pentamer motif match 9 0.052 0.022 2.2E−19
Free energy of seed binding (log2) 10 − 2.583 − 2.596 2.6E−01
Distance to UTR end (log2) 11 8.403 9.125 4.7E−126
Seed8A1, moderate phyloP score 12 0.047 0.006 7.5E−53
CA count 13 0.758 0.743 2.7E−01
Seed7b, conserved 14 0.124 0.048 8.7E−55
Seed8A1, high phyloP score 15 0.146 0.009 7.3E−218
Seed7A1, high phyloP score 16 0.036 0.014 1.0E−15
Seed7b, high phyloP score 17 0.093 0.022 8.7E−74
CT count 18 0.893 0.829 3.5E−05
CG count 19 0.106 0.128 6.4E−04
TA count 20 0.871 0.655 2.1E−45