Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data

Table 3 Summary of top-ranking miRNA targeting features identified by RFE analysis

Feature name	RFE rank	Targets	Non-targets	P value
Seed 8A1, conserved	1	0.184	0.018	2.8E−245
Seed7b, low phyloP score	2	0.273	0.445	3.2E−84
GC content of target site	3	1.554	1.901	4.9E−117
UTR length (log2)	4	10.960	11.430	1.5E−114
Seed7A1, non-conserved	5	0.142	0.341	9.5E−134
Seed7A1, low phyloP score	6	0.137	0.339	1.3E−138
AG count	7	0.517	0.774	2.6E−73
Seed8A1, low phyloP score	8	0.200	0.126	1.5E−29
Pentamer motif match	9	0.052	0.022	2.2E−19
Free energy of seed binding (log2)	10	− 2.583	− 2.596	2.6E−01
Distance to UTR end (log2)	11	8.403	9.125	4.7E−126
Seed8A1, moderate phyloP score	12	0.047	0.006	7.5E−53
CA count	13	0.758	0.743	2.7E−01
Seed7b, conserved	14	0.124	0.048	8.7E−55
Seed8A1, high phyloP score	15	0.146	0.009	7.3E−218
Seed7A1, high phyloP score	16	0.036	0.014	1.0E−15
Seed7b, high phyloP score	17	0.093	0.022	8.7E−74
CT count	18	0.893	0.829	3.5E−05
CG count	19	0.106	0.128	6.4E−04
TA count	20	0.871	0.655	2.1E−45

ISSN: 1474-760X