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Fig. 1 | Genome Biology

Fig. 1

From: The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

Fig. 1

Manual curation of cancer genes in NCG. a Pipeline used for adding cancer genes to NCG. Two sources of known cancer genes [19, 53] were integrated leading to 711 known cancer genes. In parallel, 273 publications describing cancer sequencing screens were reviewed to extract 2088 cancer genes. The non-redundant union of these two sets led to 2372 cancer genes currently annotated in NCG. b Intersection between known and candidate cancer genes in NCG. c Comparison of NCG content with the previous version [11]. d Pie chart of the methods used to identify cancer genes in the 273 publications. The total is greater than 273 because some studies used more than one method (Additional file 2: Table S2). e Cancer genes as a function of the number of cancer donors per study. The grey inset shows a magnification of the left bottom corner of the plot. f Number of methods used to identify cancer genes over time. PanSoftware used in one of the pan-cancer studies [6] was considered as a single method but is in fact a combination of 26 prediction tools

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