Fig. 2

Circadian oscillations of absolute and relative cell counts in human white blood cell types. a, b Dynamics of a absolute count of four WBC types, and b proportion of each cell type relative to the total WBC count in four male subjects. Values are mean-centered by cell type, and solid line type indicates oscillation significance (p < 0.05). For each of the four subjects, data points with the same time of day were averaged. The lines represent harmonic regression fits, and whiskers represent the 95% confidence intervals of the between-subject mean. Data points are shifted slightly along the x-axis from their integer values to avoid whisker collisions. CT, circadian time