Fig. 1

Experimental workflow summary. Cell count measurements were taken from four individuals across 48 h. Oscillating cytosines were identified in human neutrophil samples collected from a healthy male interrogated on the Infinium HumanMethylation450K BeadChip (Illumina). We utilized publicly available datasets to uncover the circadian effects in cytosine modification differences between white blood cell fractions [21], epigenetic variation and aging [31, 32], and disease-specific cytosine modification changes [32, 34,35,36,37]. Age-modC, age-correlated cytosine modifications; osc-modC, oscillating modified cytosines; WBC, white blood cells