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Fig. 3 | Genome Biology

Fig. 3

From: Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate

Fig. 3

ERV interactions are constrained by the different levels of nuclear organization a Whole chromosome view of 4Tran-PCR signal for RLTR4 integrations on chromosomes 3 and 8. The single integrations shown for these chromosomes are highlighted with an arrow over the plot and the regions identified as significantly interacting with these sites are shown under 4Tran-PCR signal as boxes. Hi-C data is represented by the PC-score calculated for each 50 kb bin. A positive PC score is characteristic of A regions, while a negative score is associate with B regions. b Violin plots representing the PC score for all regions identified as interacting in cis with the RLTR4 integration in chromosomes 3 and 8. An integration in compartment A leads to contacts with other compartment A regions, while the reverse is true for an integration in compartment B on chromosome 8. c, d High-resolution 4Tran-PCR data is shown together with Hi-C from Ch12 B cells. Hi-C is shown using both principal component score and 25 Kb-bins. Dashed lines highlight regions of high 4Tran-PCR signal and borders of domains, as described in the “Results” section

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