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Table 1 Recent progress of cancer studies based on single-cell sequencing

From: Understanding tumor ecosystems by single-cell sequencing: promises and limitations

Technology Study topic References
Single-cell DNA-seq Heterogeneity of cancer clones [18, 33, 40, 45, 157]
Single-cell DNA-seq Mutation profiles of CTCs [16, 43]
Single-cell RNA-seq Expression patterns of cancer cells upon treatment [19, 29, 46, 165]
Single-cell RNA-seq Expression heterogeneity and dynamics of cancer cells [22, 37, 38, 41, 44]
Single-cell RNA-seq Expression patterns of CTCs [31]
Single-cell RNA-seq Heterogeneity of tumor microenvironment [47,48,49,50,51,52, 55,56,57,58,59]
Single-cell RNA-seq, mass cytometry Heterogeneity of tumor microenvironment [53, 54]
Single-cell DNA-seq and RNA-seq Integrated analysis of cancer cells [20, 166]
Single-cell epigenomics Epigenomics of cancer cells [187]
Single-cell multi-omics Multi-omics analyses of the same cancer cells [32]
Single-cell-derived organoids Diversification of cancer cells [42]
Spatial single-cell sequencing Spatial heterogeneity and metastasis of cancer cells [21, 30]
Single-cell DNA-seq Amplification methods [7, 8, 39, 40, 172, 206,207,208]