Table 2 Examples of genome editing for disease resistance and other production traits

Increased muscle growth (double-muscle phenotype)

Cow

Myostatin (GDF8)

[56]

Sheep

Myostatin (GDF8)

[56, 57]

Goat

Myostatin (GDF8)

[58]

Channel Catfish

Myostatin (GDF8)

[59]

Pig

Myostatin (GDF8)

[60,61,62,63,64,65,66]

Hornlessness (Polled)

Cow

Pc POLLED

[74]

Boretaint (Hormone release during sexual maturity leading to undesired meat taste)

Pig

KISS1R

[75]

Sterility

Salmon

Dead end protein (dnd)

[78]

Sterility/surrogate hosts

Pig

Nanos2

[79]

Chicken

DDX4 (Vasa)

[80]

PRRSV resistance

Pig

CD163

[90,91,92,93]

ASFV resilience

Pig

RELA

[95, 96]

Mannheimia (Pasteurella) haemolytica resilience

Cow

CD18

[97]

Bovine tuberculosis resilience

Cow

NRAMP1

[99]

Xenotransplantation (removal of endogenous retroviruses)

Pig

Porcine endogenous retrovirus genes

[106, 107]