Skip to main content
Fig. 3 | Genome Biology

Fig. 3

From: GRIPT: a novel case-control analysis method for Mendelian disease gene discovery

Fig. 3

Simulation analysis of GRIPT, VAAST2, CMC, SKAT, and KBAC under the AR and AD models. The AR and AD models were tested with 0.5%, 1%, 2%, and 3% of patients carrying the pathogenic mutations of RPE65 or TINF2, respectively. The patient cohort size was 600. The control cohort size was 5000. The performance of GRIPT, VAAST2, CMC, SKAT, and KBAC are shown in red, blue, green, purple, and orange, respectively. a The ranking of RPE65 under the AR model is shown in the boxplot. b The power of the five tools were measured as the proportion of simulation runs in which PRE65 passed the GWSL shown in the dot plot. c The number of significant autosomal candidate genes under the AR model is shown in the boxplot. d The ranking of TINF2 under the AD model. e The power of the five tools for TINF2. f The number of significant autosomal candidates under the AD model. The rankings of RPE65/TINF2 generated by GRIPT were compared to those generated by the other four methods respectively with one-tailed WRST. The methods that generated significantly worse ranking than GRIPT were marked with “*” if p value < 0.05, “**” if p value < 0.01, and “***” if p value < 0.001

Back to article page