Fig. 2From: CODEX2: full-spectrum copy number variation detection by high-throughput DNA sequencingOutline of the analysis framework with a benchmark against SVD-based methods. Results are based on in silico simulations where the ground truth with one-dimensional latent factor is known. One CNV signal is correlated with batch effect, and the other is not. CODEX2 utilizes negative control samples and negative control regions and outperforms SVD-based methodsBack to article page