TY - JOUR AU - Lister, R. AU - Mukamel, E. A. AU - Nery, J. R. AU - Urich, M. AU - Puddifoot, C. A. AU - Johnson, N. D. PY - 2013 DA - 2013// TI - Global epigenomic reconfiguration during mammalian brain development JO - Science VL - 341 UR - https://doi.org/10.1126/science.1237905 DO - 10.1126/science.1237905 ID - Lister2013 ER - TY - JOUR AU - Lister, R. AU - Pelizzola, M. AU - Dowen, R. H. AU - Hawkins, R. D. AU - Hon, G. AU - Tonti-Filippini, J. PY - 2009 DA - 2009// TI - Human DNA methylomes at base resolution show widespread epigenomic differences JO - Nature VL - 462 UR - https://doi.org/10.1038/nature08514 DO - 10.1038/nature08514 ID - Lister2009 ER - TY - JOUR AU - Varley, K. E. AU - Gertz, J. AU - Bowling, K. M. AU - Parker, S. L. AU - Reddy, T. E. AU - Pauli-Behn, F. PY - 2013 DA - 2013// TI - Dynamic DNA methylation across diverse human cell lines and tissues JO - Genome Res VL - 23 UR - https://doi.org/10.1101/gr.147942.112 DO - 10.1101/gr.147942.112 ID - Varley2013 ER - TY - JOUR AU - Kulis, M. AU - Merkel, A. AU - Heath, S. AU - Queiros, A. C. AU - Schuyler, R. P. AU - Castellano, G. PY - 2015 DA - 2015// TI - Whole-genome fingerprint of the DNA methylome during human B cell differentiation JO - Nat Genet VL - 47 UR - https://doi.org/10.1038/ng.3291 DO - 10.1038/ng.3291 ID - Kulis2015 ER - TY - JOUR AU - Reik, W. AU - Walter, J. PY - 2001 DA - 2001// TI - Genomic imprinting: parental influence on the genome JO - Nat Rev Genet VL - 2 UR - https://doi.org/10.1038/35047554 DO - 10.1038/35047554 ID - Reik2001 ER - TY - JOUR AU - Chaligne, R. AU - Heard, E. PY - 2014 DA - 2014// TI - X-chromosome inactivation in development and cancer JO - FEBS Lett VL - 588 UR - https://doi.org/10.1016/j.febslet.2014.06.023 DO - 10.1016/j.febslet.2014.06.023 ID - Chaligne2014 ER - TY - JOUR AU - Koch, A. AU - Joosten, S. C. AU - Feng, Z. AU - de Ruijter, T. C. AU - Draht, M. X. AU - Melotte, V. PY - 2018 DA - 2018// TI - Analysis of DNA methylation in cancer: location revisited JO - Nat Rev Clin Oncol VL - 15 UR - https://doi.org/10.1038/s41571-018-0004-4 DO - 10.1038/s41571-018-0004-4 ID - Koch2018 ER - TY - JOUR AU - Klein, H. U. AU - De Jager, P. L. PY - 2016 DA - 2016// TI - Uncovering the role of the methylome in dementia and neurodegeneration JO - Trends Mol Med VL - 22 UR - https://doi.org/10.1016/j.molmed.2016.06.008 DO - 10.1016/j.molmed.2016.06.008 ID - Klein2016 ER - TY - JOUR AU - Gaj, T. AU - Gersbach, C. A. AU - Barbas, C. F. PY - 2013 DA - 2013// TI - ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering JO - Trends Biotechnol VL - 31 UR - https://doi.org/10.1016/j.tibtech.2013.04.004 DO - 10.1016/j.tibtech.2013.04.004 ID - Gaj2013 ER - TY - JOUR AU - Xu, G. L. AU - Bestor, T. H. PY - 1997 DA - 1997// TI - Cytosine methylation targetted to pre-determined sequences JO - Nat Genet VL - 17 UR - https://doi.org/10.1038/ng1297-376 DO - 10.1038/ng1297-376 ID - Xu1997 ER - TY - JOUR AU - McNamara, A. R. AU - Hurd, P. J. AU - Smith, A. E. AU - Ford, K. G. PY - 2002 DA - 2002// TI - Characterisation of site-biased DNA methyltransferases: specificity, affinity and subsite relationships JO - Nucleic Acids Res VL - 30 UR - https://doi.org/10.1093/nar/gkf501 DO - 10.1093/nar/gkf501 ID - McNamara2002 ER - TY - JOUR AU - Smith, A. E. AU - Ford, K. G. PY - 2007 DA - 2007// TI - Specific targeting of cytosine methylation to DNA sequences in vivo JO - Nucleic Acids Res VL - 35 UR - https://doi.org/10.1093/nar/gkl1053 DO - 10.1093/nar/gkl1053 ID - Smith2007 ER - TY - JOUR AU - Carvin, C. D. AU - Parr, R. D. AU - Kladde, M. P. PY - 2003 DA - 2003// TI - Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins JO - Nucleic Acids Res VL - 31 UR - https://doi.org/10.1093/nar/gkg853 DO - 10.1093/nar/gkg853 ID - Carvin2003 ER - TY - JOUR AU - Pattanayak, V. AU - Ramirez, C. L. AU - Joung, J. K. AU - Liu, D. R. PY - 2011 DA - 2011// TI - Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection JO - Nat Methods VL - 8 UR - https://doi.org/10.1038/nmeth.1670 DO - 10.1038/nmeth.1670 ID - Pattanayak2011 ER - TY - JOUR AU - Gabriel, R. AU - Lombardo, A. AU - Arens, A. AU - Miller, J. C. AU - Genovese, P. AU - Kaeppel, C. PY - 2011 DA - 2011// TI - An unbiased genome-wide analysis of zinc-finger nuclease specificity JO - Nat Biotechnol VL - 29 UR - https://doi.org/10.1038/nbt.1948 DO - 10.1038/nbt.1948 ID - Gabriel2011 ER - TY - JOUR AU - Vandevenne, M. AU - Jacques, D. A. AU - Artuz, C. AU - Nguyen, C. D. AU - Kwan, A. H. AU - Segal, D. J. PY - 2013 DA - 2013// TI - New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217 JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M112.441451 DO - 10.1074/jbc.M112.441451 ID - Vandevenne2013 ER - TY - JOUR AU - Rivenbark, A. G. AU - Stolzenburg, S. AU - Beltran, A. S. AU - Yuan, X. AU - Rots, M. G. AU - Strahl, B. D. AU - Blancafort, P. PY - 2012 DA - 2012// TI - Epigenetic reprogramming of cancer cells via targeted DNA methylation JO - Epigenetics. VL - 7 UR - https://doi.org/10.4161/epi.19507 DO - 10.4161/epi.19507 ID - Rivenbark2012 ER - TY - JOUR AU - Chaikind, B. AU - Ostermeier, M. PY - 2014 DA - 2014// TI - Directed evolution of improved zinc finger methyltransferases JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0096931 DO - 10.1371/journal.pone.0096931 ID - Chaikind2014 ER - TY - JOUR AU - Nunna, S. AU - Reinhardt, R. AU - Ragozin, S. AU - Jeltsch, A. PY - 2014 DA - 2014// TI - Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0087703 DO - 10.1371/journal.pone.0087703 ID - Nunna2014 ER - TY - JOUR AU - Li, F. AU - Papworth, M. AU - Minczuk, M. AU - Rohde, C. AU - Zhang, Y. AU - Ragozin, S. AU - Jeltsch, A. PY - 2007 DA - 2007// TI - Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes JO - Nucleic Acids Res VL - 35 UR - https://doi.org/10.1093/nar/gkl1035 DO - 10.1093/nar/gkl1035 ID - Li2007 ER - TY - JOUR AU - de Groote, M. L. AU - Verschure, P. J. AU - Rots, M. G. PY - 2012 DA - 2012// TI - Epigenetic editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes JO - Nucleic Acids Res VL - 40 UR - https://doi.org/10.1093/nar/gks863 DO - 10.1093/nar/gks863 ID - de Groote2012 ER - TY - JOUR AU - Siddique, A. N. AU - Nunna, S. AU - Rajavelu, A. AU - Zhang, Y. AU - Jurkowska, R. Z. AU - Reinhardt, R. PY - 2013 DA - 2013// TI - Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a–Dnmt3L single-chain fusion protein with increased DNA methylation activity JO - J Mol Biol VL - 425 UR - https://doi.org/10.1016/j.jmb.2012.11.038 DO - 10.1016/j.jmb.2012.11.038 ID - Siddique2013 ER - TY - JOUR AU - Stolzenburg, S. AU - Beltran, A. S. AU - Swift-Scanlan, T. AU - Rivenbark, A. G. AU - Rashwan, R. AU - Blancafort, P. PY - 2015 DA - 2015// TI - Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer JO - Oncogene VL - 34 UR - https://doi.org/10.1038/onc.2014.470 DO - 10.1038/onc.2014.470 ID - Stolzenburg2015 ER - TY - JOUR AU - Cui, C. AU - Gan, Y. AU - Gu, L. AU - Wilson, J. AU - Liu, Z. AU - Zhang, B. AU - Deng, D. PY - 2015 DA - 2015// TI - P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis JO - Genome Biol VL - 16 UR - https://doi.org/10.1186/s13059-015-0819-6 DO - 10.1186/s13059-015-0819-6 ID - Cui2015 ER - TY - JOUR AU - Minczuk, M. AU - Papworth, M. A. AU - Kolasinska, P. AU - Murphy, M. P. AU - Klug, A. PY - 2006 DA - 2006// TI - Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0609502103 DO - 10.1073/pnas.0609502103 ID - Minczuk2006 ER - TY - JOUR AU - Meister, G. E. AU - Chandrasegaran, S. AU - Ostermeier, M. PY - 2008 DA - 2008// TI - An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity JO - Biochem Biophys Res Commun VL - 377 UR - https://doi.org/10.1016/j.bbrc.2008.09.099 DO - 10.1016/j.bbrc.2008.09.099 ID - Meister2008 ER - TY - JOUR AU - Meister, G. E. AU - Chandrasegaran, S. AU - Ostermeier, M. PY - 2010 DA - 2010// TI - Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells JO - Nucleic Acids Res VL - 38 UR - https://doi.org/10.1093/nar/gkp1126 DO - 10.1093/nar/gkp1126 ID - Meister2010 ER - TY - JOUR AU - Nomura, W. AU - Barbas, C. F. PY - 2007 DA - 2007// TI - In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase JO - J Am Chem Soc VL - 129 UR - https://doi.org/10.1021/ja0705588 DO - 10.1021/ja0705588 ID - Nomura2007 ER - TY - JOUR AU - Smith, A. E. AU - Hurd, P. J. AU - Bannister, A. J. AU - Kouzarides, T. AU - Ford, K. G. PY - 2008 DA - 2008// TI - Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus JO - J Biol Chem VL - 283 UR - https://doi.org/10.1074/jbc.M710393200 DO - 10.1074/jbc.M710393200 ID - Smith2008 ER - TY - JOUR AU - Carvin, C. D. AU - Dhasarathy, A. AU - Friesenhahn, L. B. AU - Jessen, W. J. AU - Kladde, M. P. PY - 2003 DA - 2003// TI - Targeted cytosine methylation for in vivo detection of protein–DNA interactions JO - Proc Natl Acad Sci U S A VL - 100 UR - https://doi.org/10.1073/pnas.1332672100 DO - 10.1073/pnas.1332672100 ID - Carvin2003 ER - TY - JOUR AU - Boch, J. AU - Scholze, H. AU - Schornack, S. AU - Landgraf, A. AU - Hahn, S. AU - Kay, S. PY - 2009 DA - 2009// TI - Breaking the code of DNA binding specificity of TAL-type III effectors JO - Science VL - 326 UR - https://doi.org/10.1126/science.1178811 DO - 10.1126/science.1178811 ID - Boch2009 ER - TY - JOUR AU - Moscou, M. J. AU - Bogdanove, A. J. PY - 2009 DA - 2009// TI - A simple cipher governs DNA recognition by TAL effectors JO - Science VL - 326 UR - https://doi.org/10.1126/science.1178817 DO - 10.1126/science.1178817 ID - Moscou2009 ER - TY - JOUR AU - Bernstein, D. L. AU - Le Lay, J. E. AU - Ruano, E. G. AU - Kaestner, K. H. PY - 2015 DA - 2015// TI - TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts JO - J Clin Invest VL - 125 UR - https://doi.org/10.1172/JCI77321 DO - 10.1172/JCI77321 ID - Bernstein2015 ER - TY - JOUR AU - Lo, C. L. AU - Choudhury, S. R. AU - Irudayaraj, J. AU - Zhou, F. C. PY - 2017 DA - 2017// TI - Epigenetic editing of Ascl1 gene in neural stem cells by optogenetics JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/srep42047 DO - 10.1038/srep42047 ID - Lo2017 ER - TY - JOUR AU - Valton, J. AU - Dupuy, A. AU - Daboussi, F. AU - Thomas, S. AU - Marechal, A. AU - Macmaster, R. PY - 2012 DA - 2012// TI - Overcoming transcription activator-like effector (TALE) DNA binding domain sensitivity to cytosine methylation JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.C112.408864 DO - 10.1074/jbc.C112.408864 ID - Valton2012 ER - TY - JOUR AU - Kaya, H. AU - Numa, H. AU - Nishizawa-Yokoi, A. AU - Toki, S. AU - Habu, Y. PY - 2017 DA - 2017// TI - DNA methylation affects the efficiency of transcription activator-like effector nucleases-mediated genome editing in rice JO - Front Plant Sci VL - 8 UR - https://doi.org/10.3389/fpls.2017.00302 DO - 10.3389/fpls.2017.00302 ID - Kaya2017 ER - TY - JOUR AU - Hsu, P. D. AU - Lander, E. S. AU - Zhang, F. PY - 2014 DA - 2014// TI - Development and applications of CRISPR-Cas9 for genome engineering JO - Cell VL - 157 UR - https://doi.org/10.1016/j.cell.2014.05.010 DO - 10.1016/j.cell.2014.05.010 ID - Hsu2014 ER - TY - JOUR AU - Vojta, A. AU - Dobrinic, P. AU - Tadic, V. AU - Bockor, L. AU - Korac, P. AU - Julg, B. PY - 2016 DA - 2016// TI - Repurposing the CRISPR-Cas9 system for targeted DNA methylation JO - Nucleic Acids Res VL - 44 UR - https://doi.org/10.1093/nar/gkw159 DO - 10.1093/nar/gkw159 ID - Vojta2016 ER - TY - JOUR AU - McDonald, J. I. AU - Celik, H. AU - Rois, L. E. AU - Fishberger, G. AU - Fowler, T. AU - Rees, R. PY - 2016 DA - 2016// TI - Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation JO - Biol Open VL - 5 UR - https://doi.org/10.1242/bio.019067 DO - 10.1242/bio.019067 ID - McDonald2016 ER - TY - JOUR AU - Liu, X. S. AU - Wu, H. AU - Ji, X. AU - Stelzer, Y. AU - Wu, X. AU - Czauderna, S. PY - 2016 DA - 2016// TI - Editing DNA methylation in the mammalian genome JO - Cell VL - 167 UR - https://doi.org/10.1016/j.cell.2016.08.056 DO - 10.1016/j.cell.2016.08.056 ID - Liu2016 ER - TY - JOUR AU - Suetake, I. AU - Shinozaki, F. AU - Miyagawa, J. AU - Takeshima, H. AU - Tajima, S. PY - 2004 DA - 2004// TI - DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M400181200 DO - 10.1074/jbc.M400181200 ID - Suetake2004 ER - TY - JOUR AU - Jia, D. AU - Jurkowska, R. Z. AU - Zhang, X. AU - Jeltsch, A. AU - Cheng, X. PY - 2007 DA - 2007// TI - Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation JO - Nature VL - 449 UR - https://doi.org/10.1038/nature06146 DO - 10.1038/nature06146 ID - Jia2007 ER - TY - JOUR AU - Amabile, A. AU - Migliara, A. AU - Capasso, P. AU - Biffi, M. AU - Cittaro, D. AU - Naldini, L. AU - Lombardo, A. PY - 2016 DA - 2016// TI - Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing JO - Cell VL - 167 UR - https://doi.org/10.1016/j.cell.2016.09.006 DO - 10.1016/j.cell.2016.09.006 ID - Amabile2016 ER - TY - JOUR AU - Stepper, P. AU - Kungulovski, G. AU - Jurkowska, R. Z. AU - Chandra, T. AU - Krueger, F. AU - Reinhardt, R. PY - 2017 DA - 2017// TI - Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase JO - Nucleic Acids Res VL - 45 UR - https://doi.org/10.1093/nar/gkw1112 DO - 10.1093/nar/gkw1112 ID - Stepper2017 ER - TY - JOUR AU - Tanenbaum, M. E. AU - Gilbert, L. A. AU - Qi, L. S. AU - Weissman, J. S. AU - Vale, R. D. PY - 2014 DA - 2014// TI - A protein-tagging system for signal amplification in gene expression and fluorescence imaging JO - Cell VL - 159 UR - https://doi.org/10.1016/j.cell.2014.09.039 DO - 10.1016/j.cell.2014.09.039 ID - Tanenbaum2014 ER - TY - JOUR AU - Morita, S. AU - Noguchi, H. AU - Horii, T. AU - Nakabayashi, K. AU - Kimura, M. AU - Okamura, K. PY - 2016 DA - 2016// TI - Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions JO - Nat Biotechnol VL - 34 UR - https://doi.org/10.1038/nbt.3658 DO - 10.1038/nbt.3658 ID - Morita2016 ER - TY - JOUR AU - Huang, Y. H. AU - Su, J. AU - Lei, Y. AU - Brunetti, L. AU - Gundry, M. C. AU - Zhang, X. PY - 2017 DA - 2017// TI - DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A JO - Genome Biol VL - 18 UR - https://doi.org/10.1186/s13059-017-1306-z DO - 10.1186/s13059-017-1306-z ID - Huang2017 ER - TY - JOUR AU - Lei, Y. AU - Zhang, X. AU - Su, J. AU - Jeong, M. AU - Gundry, M. C. AU - Huang, Y. H. PY - 2017 DA - 2017// TI - Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein JO - Nat Commun VL - 8 UR - https://doi.org/10.1038/ncomms16026 DO - 10.1038/ncomms16026 ID - Lei2017 ER - TY - JOUR AU - Xiong, T. AU - Meister, G. E. AU - Workman, R. E. AU - Kato, N. C. AU - Spellberg, M. J. AU - Turker, F. PY - 2017 DA - 2017// TI - Targeted DNA methylation in human cells using engineered dCas9-methyltransferases JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-06757-0 DO - 10.1038/s41598-017-06757-0 ID - Xiong2017 ER - TY - JOUR AU - Gregory, D. J. AU - Mikhaylova, L. AU - Fedulov, A. V. PY - 2012 DA - 2012// TI - Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain JO - Epigenetics VL - 7 UR - https://doi.org/10.4161/epi.19509 DO - 10.4161/epi.19509 ID - Gregory2012 ER - TY - JOUR AU - Gregory, D. J. AU - Zhang, Y. AU - Kobzik, L. AU - Fedulov, A. V. PY - 2013 DA - 2013// TI - Specific transcriptional enhancement of inducible nitric oxide synthase by targeted promoter demethylation JO - Epigenetics. VL - 8 UR - https://doi.org/10.4161/epi.26267 DO - 10.4161/epi.26267 ID - Gregory2013 ER - TY - JOUR AU - Chen, H. AU - Kazemier, H. G. AU - de Groote, M. L. AU - Ruiters, M. H. AU - Xu, G. L. AU - Rots, M. G. PY - 2014 DA - 2014// TI - Induced DNA demethylation by targeting ten-eleven translocation 2 to the human ICAM-1 promoter JO - Nucleic Acids Res VL - 42 UR - https://doi.org/10.1093/nar/gkt1019 DO - 10.1093/nar/gkt1019 ID - Chen2014 ER - TY - JOUR AU - Maeder, M. L. AU - Angstman, J. F. AU - Richardson, M. E. AU - Linder, S. J. AU - Cascio, V. M. AU - Tsai, S. Q. PY - 2013 DA - 2013// TI - Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins JO - Nat Biotechnol VL - 31 UR - https://doi.org/10.1038/nbt.2726 DO - 10.1038/nbt.2726 ID - Maeder2013 ER - TY - JOUR AU - Pflueger, C. AU - Tan, D. AU - Swain, T. AU - Nguyen, T. AU - Pflueger, J. AU - Nefzger, C. PY - 2018 DA - 2018// TI - A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs JO - Genome Res VL - 28 UR - https://doi.org/10.1101/gr.233049.117 DO - 10.1101/gr.233049.117 ID - Pflueger2018 ER - TY - JOUR AU - Galonska, C. AU - Charlton, J. AU - Mattei, A. L. AU - Donaghey, J. AU - Clement, K. AU - Gu, H. PY - 2018 DA - 2018// TI - Genome-wide tracking of dCas9-methyltransferase footprints JO - Nat Commun VL - 9 UR - https://doi.org/10.1038/s41467-017-02708-5 DO - 10.1038/s41467-017-02708-5 ID - Galonska2018 ER - TY - JOUR AU - Choudhury, S. R. AU - Cui, Y. AU - Lubecka, K. AU - Stefanska, B. AU - Irudayaraj, J. PY - 2016 DA - 2016// TI - CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter JO - Oncotarget VL - 7 ID - Choudhury2016 ER - TY - JOUR AU - Xu, X. AU - Tao, Y. AU - Gao, X. AU - Zhang, L. AU - Li, X. AU - Zou, W. PY - 2016 DA - 2016// TI - A CRISPR-based approach for targeted DNA demethylation JO - Cell Discov VL - 2 UR - https://doi.org/10.1038/celldisc.2016.9 DO - 10.1038/celldisc.2016.9 ID - Xu2016 ER - TY - JOUR AU - Liu, X. S. AU - Wu, H. AU - Krzisch, M. AU - Wu, X. AU - Graef, J. AU - Muffat, J. PY - 2018 DA - 2018// TI - Rescue of Fragile X syndrome neurons by DNA methylation editing of the FMR1 gene JO - Cell VL - 172 UR - https://doi.org/10.1016/j.cell.2018.01.012 DO - 10.1016/j.cell.2018.01.012 ID - Liu2018 ER - TY - JOUR AU - Parrilla-Doblas, J. T. AU - Ariza, R. R. AU - Roldan-Arjona, T. PY - 2017 DA - 2017// TI - Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain JO - Epigenetics. VL - 12 UR - https://doi.org/10.1080/15592294.2017.1294306 DO - 10.1080/15592294.2017.1294306 ID - Parrilla-Doblas2017 ER - TY - JOUR AU - Kass, S. U. AU - Pruss, D. AU - Wolffe, A. P. PY - 1997 DA - 1997// TI - How does DNA methylation repress transcription? JO - Trends Genet VL - 13 UR - https://doi.org/10.1016/S0168-9525(97)01268-7 DO - 10.1016/S0168-9525(97)01268-7 ID - Kass1997 ER - TY - JOUR AU - Miranda, T. B. AU - Jones, P. A. PY - 2007 DA - 2007// TI - DNA methylation: the nuts and bolts of repression JO - J Cell Physiol VL - 213 UR - https://doi.org/10.1002/jcp.21224 DO - 10.1002/jcp.21224 ID - Miranda2007 ER - TY - JOUR AU - Su, J. AU - Huang, Y. H. AU - Cui, X. AU - Wang, X. AU - Zhang, X. AU - Lei, Y. PY - 2018 DA - 2018// TI - Homeobox oncogene activation by pan-cancer DNA hypermethylation JO - Genome Biol VL - 19 UR - https://doi.org/10.1186/s13059-018-1492-3 DO - 10.1186/s13059-018-1492-3 ID - Su2018 ER - TY - JOUR AU - Dowen, J. M. AU - Fan, Z. P. AU - Hnisz, D. AU - Ren, G. AU - Abraham, B. J. AU - Zhang, L. N. PY - 2014 DA - 2014// TI - Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes JO - Cell VL - 159 UR - https://doi.org/10.1016/j.cell.2014.09.030 DO - 10.1016/j.cell.2014.09.030 ID - Dowen2014 ER - TY - JOUR AU - Qi, L. S. AU - Larson, M. H. AU - Gilbert, L. A. AU - Doudna, J. A. AU - Weissman, J. S. AU - Arkin, A. P. AU - Lim, W. A. PY - 2013 DA - 2013// TI - Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression JO - Cell VL - 152 UR - https://doi.org/10.1016/j.cell.2013.02.022 DO - 10.1016/j.cell.2013.02.022 ID - Qi2013 ER - TY - JOUR AU - O'Geen, H. AU - Ren, C. AU - Nicolet, C. M. AU - Perez, A. A. AU - Halmai, J. AU - Le, V. M. PY - 2017 DA - 2017// TI - dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression JO - Nucleic Acids Res VL - 45 UR - https://doi.org/10.1093/nar/gkx578 DO - 10.1093/nar/gkx578 ID - O'Geen2017 ER - TY - JOUR AU - Nishimasu, H. AU - Ran, F. A. AU - Hsu, P. D. AU - Konermann, S. AU - Shehata, S. I. AU - Dohmae, N. PY - 2014 DA - 2014// TI - Crystal structure of Cas9 in complex with guide RNA and target DNA JO - Cell VL - 156 UR - https://doi.org/10.1016/j.cell.2014.02.001 DO - 10.1016/j.cell.2014.02.001 ID - Nishimasu2014 ER - TY - JOUR AU - Kuscu, C. AU - Arslan, S. AU - Singh, R. AU - Thorpe, J. AU - Adli, M. PY - 2014 DA - 2014// TI - Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease JO - Nat Biotechnol VL - 32 UR - https://doi.org/10.1038/nbt.2916 DO - 10.1038/nbt.2916 ID - Kuscu2014 ER - TY - JOUR AU - Ehrlich, M. AU - Gama-Sosa, M. A. AU - Huang, L. H. AU - Midgett, R. M. AU - Kuo, K. C. AU - McCune, R. A. AU - Gehrke, C. PY - 1982 DA - 1982// TI - Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells JO - Nucleic Acids Res VL - 10 UR - https://doi.org/10.1093/nar/10.8.2709 DO - 10.1093/nar/10.8.2709 ID - Ehrlich1982 ER - TY - JOUR AU - Laurent, L. AU - Wong, E. AU - Li, G. AU - Huynh, T. AU - Tsirigos, A. AU - Ong, C. T. PY - 2010 DA - 2010// TI - Dynamic changes in the human methylome during differentiation JO - Genome Res VL - 20 UR - https://doi.org/10.1101/gr.101907.109 DO - 10.1101/gr.101907.109 ID - Laurent2010 ER - TY - JOUR AU - Ramsahoye, B. H. AU - Biniszkiewicz, D. AU - Lyko, F. AU - Clark, V. AU - Bird, A. P. AU - Jaenisch, R. PY - 2000 DA - 2000// TI - Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a JO - Proc Natl Acad Sci U S A VL - 97 UR - https://doi.org/10.1073/pnas.97.10.5237 DO - 10.1073/pnas.97.10.5237 ID - Ramsahoye2000 ER - TY - JOUR AU - Lister, R. AU - Pelizzola, M. AU - Kida, Y. S. AU - Hawkins, R. D. AU - Nery, J. R. AU - Hon, G. PY - 2011 DA - 2011// TI - Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells JO - Nature VL - 471 UR - https://doi.org/10.1038/nature09798 DO - 10.1038/nature09798 ID - Lister2011 ER - TY - JOUR AU - Ziller, M. J. AU - Muller, F. AU - Liao, J. AU - Zhang, Y. AU - Gu, H. AU - Bock, C. PY - 2011 DA - 2011// TI - Genomic distribution and inter-sample variation of non-CpG methylation across human cell types JO - PLoS Genet VL - 7 UR - https://doi.org/10.1371/journal.pgen.1002389 DO - 10.1371/journal.pgen.1002389 ID - Ziller2011 ER - TY - JOUR AU - Guo, J. U. AU - Su, Y. AU - Shin, J. H. AU - Shin, J. AU - Li, H. AU - Xie, B. PY - 2014 DA - 2014// TI - Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain JO - Nat Neurosci VL - 17 UR - https://doi.org/10.1038/nn.3607 DO - 10.1038/nn.3607 ID - Guo2014 ER - TY - JOUR AU - Chen, L. AU - Chen, K. AU - Lavery, L. A. AU - Baker, S. A. AU - Shaw, C. A. AU - Li, W. AU - Zoghbi, H. Y. PY - 2015 DA - 2015// TI - MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome JO - Proc Natl Acad Sci U S A VL - 112 UR - https://doi.org/10.1073/pnas.1505909112 DO - 10.1073/pnas.1505909112 ID - Chen2015 ER - TY - JOUR AU - Kinde, B. AU - Gabel, H. W. AU - Gilbert, C. S. AU - Griffith, E. C. AU - Greenberg, M. E. PY - 2015 DA - 2015// TI - Reading the unique DNA methylation landscape of the brain: non-CpG methylation, hydroxymethylation, and MeCP2 JO - Proc Natl Acad Sci U S A VL - 112 UR - https://doi.org/10.1073/pnas.1411269112 DO - 10.1073/pnas.1411269112 ID - Kinde2015 ER - TY - JOUR AU - Zhang, Z. M. AU - Lu, R. AU - Wang, P. AU - Yu, Y. AU - Chen, D. AU - Gao, L. PY - 2018 DA - 2018// TI - Structural basis for DNMT3A-mediated de novo DNA methylation JO - Nature VL - 554 UR - https://doi.org/10.1038/nature25477 DO - 10.1038/nature25477 ID - Zhang2018 ER - TY - JOUR AU - Nile, C. J. AU - Read, R. C. AU - Akil, M. AU - Duff, G. W. AU - Wilson, A. G. PY - 2008 DA - 2008// TI - Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis JO - Arthritis Rheum VL - 58 UR - https://doi.org/10.1002/art.23758 DO - 10.1002/art.23758 ID - Nile2008 ER - TY - JOUR AU - Jinek, M. AU - Chylinski, K. AU - Fonfara, I. AU - Hauer, M. AU - Doudna, J. A. AU - Charpentier, E. PY - 2012 DA - 2012// TI - A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity JO - Science VL - 337 UR - https://doi.org/10.1126/science.1225829 DO - 10.1126/science.1225829 ID - Jinek2012 ER - TY - JOUR AU - Kleinstiver, B. P. AU - Prew, M. S. AU - Tsai, S. Q. AU - Topkar, V. V. AU - Nguyen, N. T. AU - Zheng, Z. PY - 2015 DA - 2015// TI - Engineered CRISPR-Cas9 nucleases with altered PAM specificities JO - Nature VL - 523 UR - https://doi.org/10.1038/nature14592 DO - 10.1038/nature14592 ID - Kleinstiver2015 ER - TY - JOUR AU - Ran, F. A. AU - Cong, L. AU - Yan, W. X. AU - Scott, D. A. AU - Gootenberg, J. S. AU - Kriz, A. J. PY - 2015 DA - 2015// TI - In vivo genome editing using Staphylococcus aureus Cas9 JO - Nature VL - 520 UR - https://doi.org/10.1038/nature14299 DO - 10.1038/nature14299 ID - Ran2015 ER - TY - JOUR AU - Zetsche, B. AU - Gootenberg, J. S. AU - Abudayyeh, O. O. AU - Slaymaker, I. M. AU - Makarova, K. S. AU - Essletzbichler, P. PY - 2015 DA - 2015// TI - Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system JO - Cell VL - 163 UR - https://doi.org/10.1016/j.cell.2015.09.038 DO - 10.1016/j.cell.2015.09.038 ID - Zetsche2015 ER - TY - STD TI - Ford E, Grimmer MR, Stolzenburg S, Bogdanovic O, Mendoza A, Farnham PJ, et al. Frequent lack of repressive capacity of promoter DNA methylation identified through genome-wide epigenomic manipulation. bioRxiv. 170506. doi: https://doi.org/https://doi.org/10.1101/170506. ID - ref82 ER - TY - JOUR AU - Wiznerowicz, M. AU - Jakobsson, J. AU - Szulc, J. AU - Liao, S. AU - Quazzola, A. AU - Beermann, F. PY - 2007 DA - 2007// TI - The Kruppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M705898200 DO - 10.1074/jbc.M705898200 ID - Wiznerowicz2007 ER - TY - JOUR AU - Ying, Y. AU - Yang, X. AU - Zhao, K. AU - Mao, J. AU - Kuang, Y. AU - Wang, Z. PY - 2015 DA - 2015// TI - The Kruppel-associated box repressor domain induces reversible and irreversible regulation of endogenous mouse genes by mediating different chromatin states JO - Nucleic Acids Res VL - 43 UR - https://doi.org/10.1093/nar/gkv016 DO - 10.1093/nar/gkv016 ID - Ying2015 ER - TY - JOUR AU - Takahashi, Y. AU - Wu, J. AU - Suzuki, K. AU - Martinez-Redondo, P. AU - Li, M. AU - Liao, H. K. PY - 2017 DA - 2017// TI - Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells JO - Science VL - 356 UR - https://doi.org/10.1126/science.aag3260 DO - 10.1126/science.aag3260 ID - Takahashi2017 ER -