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Fig. 4 | Genome Biology

Fig. 4

From: Phytophthora methylomes are modulated by 6mA methyltransferases and associated with adaptive genome regions

Fig. 4

6mA marks Phytophthora repetitive elements and highlights gene-sparse region. a Pie charts illustrate that 6mA peaks are predominantly distributed in repeat sequences in P. infestans and P. sojae. b Genes occupying the gene-sparse regions (GSR) display higher levels of 6mA than genes occupying the gene-dense region (GDR) in P. infestans and P. sojae. In P. infestans, GSR-occupying genes (n = 3920) and GDR-occupying genes (n = 6526) were calculated. In P. sojae, GSR-occupying genes (n = 3154) and GDR-occupying genes (n = 7240) were calculated. c Heatmap analyses reveal that 6mA accumulate in P. infestans and P. sojae GSR. All the genes in each genome were sorted into two-dimensional bins on the basis of the lengths of flanking intergenic distances to neighboring genes at their 5′ and 3′ ends. For the 6mA distribution heatmap, gradient color represents the average normalized 6mA value of genes in each bin. For the gene density distribution heatmap, gradient color represents the number of genes in each bin. The dotted line highlights GDR

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