Fig. 6
From: Genetic disease risks can be misestimated across global populations
Genetic risk scores (GRS) before and after correcting for ancestral and derived risk alleles. GRS probability densities for each continental population are shown (solid lines, uncorrected GRS; dashed lines, corrected GRS for African genomes). n = number of disease-associated loci per disease category. Arrows indicate the shift in African GRS after correcting for whether risk alleles are ancestral or derived. “*” indicates uncorrected African GRS that are significantly different than non-African GRS, and “©” indicates corrected African GRS that are significantly different than non-African GRS (p values < 0.05, Mann-Whitney U tests)